Cryptic crossword clue
English female with high fever facing fuss about cold fizz 13

The most common and most likely answer to this crossword clue is the 13 letter word EFFERVESCENCE

I've seen this crossword clue in The Daily Telegraph
E
F
F
E
R
V
E
S
C
E
N
C
E

Buddy explains!

The straight part
We know that "fizz" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case fizz = effervescence.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does EFFERVESCENCE mean?

EFFERVESCENCE noun
  1. The escape of gas from solution in a liquid, especially the escape of carbon dioxide from a carbonated drink.
  2. Vivacity.
  3. Foment.

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