Cryptic crossword clue
English female with little energy, confined to bed, grumbled 6

The most common and most likely answer to this crossword clue is the 6 letter word BEEFED

I've seen this crossword clue in The Daily Telegraph
B
E
E
F
E
D

Buddy explains!

The straight part
We know that "grumbled" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case grumbled = beefed.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does BEEFED mean?

BEEFED verb
  1. To complain.
  2. To add weight or strength to; to beef up.
  3. To fart; break wind.
  4. To feud or hold a grudge against.
  5. To cry
  6. To fail or mess up.

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