The most common and most likely answer to this crossword clue is the 4 plus 2 plus 4 letter word EAST OF EDEN
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More clues leading to the result EAST OF EDEN
- Film made of one’s defeat
- Novel twist of fate does entertain in extremis
- Sent a Defoe novel, or another book
- One’s defeat unfortunately featuring in film
- Arrange Dean’s fee to film book
- Brewing of tea needs picture
- Film defeats one, after reviewing
- Sent a Defoe novel, and one by Steinbeck
- English novel, one fast read regularly adapted into film
- Fixed fees to end a novel
Buddy explains!

The straight part
We know that "film" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case film = east of eden.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.