Cryptic crossword clue
English regret getting upset about chief American card game 6

The most common and most likely answer to this crossword clue is the 6 letter word EUCHRE

I've seen this crossword clue in Independent
E
U
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H
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E

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The cryptic/wordplay part
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This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does EUCHRE mean?

EUCHRE noun
  1. A trump card game played by four players in two partnerships with a reduced deck of 24 cards.
EUCHRE verb
  1. To deceive or outwit.

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