Cryptic crossword clue
Enough! Nearly calling off trip on this 12

The most common and most likely answer to this crossword clue is the 12 letter word HALLUCINOGEN

I've seen this crossword clue in The Guardian
H
A
L
L
U
C
I
N
O
G
E
N

Buddy explains!

The straight part
We know that "trip on this" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case trip on this = hallucinogen.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HALLUCINOGEN mean?

HALLUCINOGEN noun
  1. Any substance tending to induce hallucination.

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