Cryptic crossword clue
Enterprise, say, opens up erasing last of downmarket joint 8

The most common and most likely answer to this crossword clue is the 9 plus 1 letter word STARSHIP} –

S
T
A
R
S
H
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}
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“

Buddy explains!

The straight part
We know that "Enterprise, say" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case enterprise, say = starship} –.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does STARSHIP} – mean?

STARSHIP} – noun
  1. A type of spacecraft capable of traveling to the solar systems of other stars

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