Cryptic crossword clue
Entire goal difference may determine it 10

The most common and most likely answer to this crossword clue is the 10 letter word RELEGATION

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Buddy explains!

The straight part
We know that "may determine it" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case may determine it = relegation.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does RELEGATION mean?

RELEGATION noun
  1. The act of being relegated

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