Cryptic crossword clue
Entire rota is to be changed, you can bet on it 11

The most common and most likely answer to this crossword clue is the 11 letter word TOTALISATOR

I've seen this crossword clue in The Times
T
O
T
A
L
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S
A
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R

Buddy explains!

The straight part
We know that "you can bet on it" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case you can bet on it = totalisator.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does TOTALISATOR mean?

TOTALISATOR noun
  1. (UK) the computerised system which runs parimutuel betting, calculating payoff odds, displaying them, and producing tickets based on incoming bets.

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