The most common and most likely answer to this crossword clue is the 6 letter word ENURED
E
N
U
R
E
D
More clues leading to the result ENURED
Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ENURED mean?
ENURED verb- To inure; to make accustomed or desensitized to something unpleasant due to constant exposure.
- To take effect, to be operative; used with to.