Cryptic crossword clue
Escorted round Nemo’s first sub 4

The most common and most likely answer to this crossword clue is the 4 letter word LEND

I've seen this crossword clue in The Guardian
L
E
N
D


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The straight part
We know that "sub" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case sub = lend.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does LEND mean?

LEND noun
  1. The lumbar region; loin.
  2. (of a person or animal) The loins; flank; buttocks.
LEND verb
  1. To allow to be used by someone temporarily, on condition that it or its equivalent will be returned.
  2. To make a loan.
  3. To be suitable or applicable, to fit.
  4. To afford; to grant or furnish in general.
  5. To borrow.

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