The most common and most likely answer to this crossword clue is the 8 letter word MEATIEST
M
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T
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Buddy explains!
The straight part
We know that "with the most beef, say?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case with the most beef, say? = meatiest.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MEATIEST mean?
MEATIEST adjective- Of, relating to, or containing meat.
- Resembling meat in flavour, etc.
- Of a person or a body part, large and solid.
- Substantial.