Cryptic crossword clue
Eton prepared to change rule 12

The most common and most likely answer to this crossword clue is the 12 letter word PREPONDERATE

I've seen this crossword clue in The Daily Telegraph
P
R
E
P
O
N
D
E
R
A
T
E

More clues leading to the result PREPONDERATE

Buddy explains!

The straight part
We know that "rule" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case rule = preponderate.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PREPONDERATE mean?

PREPONDERATE verb
  1. To outweigh; to be heavier than; to exceed in weight
  2. To overpower by stronger or moral power.
  3. To cause to prefer; to incline; to decide.
  4. To exceed in weight; hence, to predominate

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