The most common and most likely answer to this crossword clue is the 6 letter word FRIDAY
F
R
I
D
A
Y
More clues leading to the result FRIDAY
- Girl carrying Republican papers for 24 hours
- One died in fight — but when?
- Period in which I would always support father
- The guy you need when assistance is required one day
- Everyman would strain nerves around end of week
- One of seven, free in spirit
- I would, to get in fight just before the weekend
- When to eat fish caught in Wear?
- One of seven papers in conflict
- When passport enters brawl?
Buddy explains!

The straight part
We know that "end of week" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case end of week = friday.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.