Cryptic crossword clue
Everything inside handbag, inverted, is plastic 6

The most common and most likely answer to this crossword clue is the 6 letter word LUCITE

L
U
C
I
T
E

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The straight part
We know that "plastic" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case plastic = lucite.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does LUCITE mean?

LUCITE noun
  1. Alternative letter-case form of Lucite

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