The most common and most likely answer to this crossword clue is the 10 letter word ANTICHRIST
I've seen this crossword clue in The Times
A
N
T
I
C
H
R
I
S
T
Buddy explains!
The straight part
We know that "religious foe" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case religious foe = antichrist.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ANTICHRIST mean?
ANTICHRIST noun- One who works against the teachings of Christ.