Cryptic crossword clue
Expenses overwhelming department under Patel, Hammond and May? 2-5

The most common and most likely answer to this crossword clue is the 8 letter word CO-HOSTS

I've seen this crossword clue in Independent
C
O
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H
O
S
T
S


Buddy explains!

The straight part
We know that "Hammond and May (the TV presenters, not the politicians!)" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case hammond and may (the tv presenters, not the politicians!) = co-hosts.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CO-HOSTS mean?

CO-HOSTS noun
  1. A joint host alongside another (compare co-star).
CO-HOSTS verb
  1. To act as a joint host.
  2. To store data on a shared server (as in web hosting).

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