Cryptic crossword clue
Expert is left gambling on dollar with no gain 10

The most common and most likely answer to this crossword clue is the 10 letter word PROFITLESS

I've seen this crossword clue in The Guardian
P
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Buddy explains!

The straight part
We know that "with no gain" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case with no gain = profitless.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PROFITLESS mean?

PROFITLESS adjective
  1. Not yielding profit

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