Cryptic crossword clue
Explorer back after troubled rest — it may give anxiety 8

The most common and most likely answer to this crossword clue is the 8 letter word STRESSOR

S
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Buddy explains!

The straight part
We know that "it may give anxiety" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case it may give anxiety = stressor.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does STRESSOR mean?

STRESSOR noun
  1. An environmental condition or influence that stresses (i.e. causes stress for) an organism.

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