Cryptic crossword clue
Expression of frustration from little fellow very angry, upset 6

The most common and most likely answer to this crossword clue is the 6 letter word DAMMIT

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Buddy explains!

The straight part
We know that "Expression of frustration" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case expression of frustration = dammit.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DAMMIT mean?

DAMMIT noun
  1. The saying of the interjection, used as a general measure of anything.
DAMMIT interjection
  1. (mildly) Expressing anger, irritation, contempt, or disappointment.

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