Cryptic crossword clue
Extract of algae found in Niagara 4

The most common and most likely answer to this crossword clue is the 4 letter word AGAR

A
G
A
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Buddy explains!

The straight part
We know that "Extract of algae" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case extract of algae = agar.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does AGAR mean?

AGAR noun
  1. A gelatinous material obtained from red algae, especially Gracilaria species, used as a bacterial culture medium, in electrophoresis and as a food additive.
  2. A culture medium based on this material.

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