Cryptic crossword clue
Extreme response from more than one class in school conflict

The most common and most likely answer to this crossword clue is the 12 letter word OVERREACTION

I've seen this crossword clue in The Times
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The straight part
We know that "Extreme response" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case extreme response = overreaction.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does OVERREACTION mean?

OVERREACTION noun
  1. A reaction that is excessive.

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