The most common and most likely answer to this crossword clue is the 6 letter word BLOTTO
B
L
O
T
T
O
More clues leading to the result BLOTTO
- Drunk bishop introduces gambling game
- High billions something of interest to gamblers?
- Drunk beginning to braise game
- Legless, British ahead of game
- Drunk beginning to bet on game
- Barrel emptied by German presumably drunk
- Bowled, chance of a draw wasted
- Brahms and Liszt left in 16 briefly
- Drunk left behind briefly outside
- Drinking litres, bum virtually drunk
Buddy explains!

The straight part
We know that "Extremely drunk" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case extremely drunk = blotto.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does BLOTTO mean?
BLOTTO noun- A person who is (very) drunk or intoxicated.
- An artwork created using blots of ink or paint.
- To become or cause to become (very) drunk or intoxicated.
- To be annihilated or destroyed; to be blotted out.
- (Very) drunk or intoxicated.
- A reagent made from non-fat dry milk, phosphate buffered saline, and sodium azide, which is used to block protein binding sites for laboratory techniques such as blots and the enzyme-linked immunosorbent assay (ELISA).
- On Sulawesi: a hollowed-out tree trunk used as a boat.