Cryptic crossword clue
Extremely selfish and silly, getting up to worry over mischief 10

The most common and most likely answer to this crossword clue is the 10 letter word SHENANIGAN

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Buddy explains!

The straight part
We know that "mischief" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case mischief = shenanigan.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SHENANIGAN mean?

SHENANIGAN noun
  1. A deceitful confidence trick, or mischief causing discomfort or annoyance.

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