Cryptic crossword clue
Extremes of zoophysiology see red, short part of skull 6

The most common and most likely answer to this crossword clue is the 6 letter word ZYGOMA

Z
Y
G
O
M
A

Buddy explains!

The straight part
We know that "part of skull" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case part of skull = zygoma.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ZYGOMA mean?

ZYGOMA noun
  1. The cheekbone.

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