Cryptic crossword clue
Eyesore behind screen produces unconscious response 10

The most common and most likely answer to this crossword clue is the 10 letter word BLINDSIGHT

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Buddy explains!

The cryptic/wordplay part
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This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does BLINDSIGHT mean?

BLINDSIGHT noun
  1. The responsivity shown by some blind or partially blind people to visual stimuli of which they are not consciously aware.

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