The most common and most likely answer to this crossword clue is the 1 letter word F
I've seen this crossword clue in The Guardian
F
More clues leading to the result F
- Resist young man
- EIGHT: SIGHT [faculty] around EYE [looker] around VENT [opening]. Another nice disguise – “obviously” there should be an “F”somewhere in the answer.
- BADE, then P{resents} inside NOWELL.
- F
- 12 NEEPS/BRIEF
- Grim, finished, close to how a sulking Trump feels himself to be?
- Politicians confuse empty remonstrations with outrage
- Flasher exposes rear end outside a Republican inauguration
- Fair chance, some say
- Organ for which I’ll pay and get ultimately some hard puzzles?
Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does F mean?
F interjection- Used to profess respect for a deceased person, or for something that has been lost.
- Used to express regret or disappointment about an unfortunate event or piece of information.
- (abbreviation) Folio, paper and book size (10"-12.5" x 15"-20")
- Fuck
- That which is feminine.
- (possibly obsolete) A woman.
- (grammar) The feminine gender.
- (grammar) A word of the feminine gender.