The most common and most likely answer to this crossword clue is the 8 letter word BACTERIA
I've seen this crossword clue in The Guardian
B
A
C
T
E
R
I
A
More clues leading to the result BACTERIA
- Bugs bit ear badly, a Charlie admitted
- Reportedly returned, more upset, to find micro-organisms
- Soviet police chief introduces law that could lay people low
- Stalin’s enforcer concealed routine bugs
- I ate crab at sea, hence my indigestion?
- Potential health risks of tailless camel eating earth
- African carrier not entirely accepting European cause of disease, possibly
- Cause of illness in kind of camel endlessly needing drug injected
- Stalin’s secret police chief conceals pretend bugs
- Bugs I found in seedy cabaret
Buddy explains!

The straight part
We know that "micro-organisms" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case micro-organisms = bacteria.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does BACTERIA mean?
BACTERIA noun- A type, species, or strain of bacterium.
- A derisive term for a lowlife or a slob (could be treated as plural or singular).
- A single celled organism with cell walls but no nucleus or organelles.
- An oval bacterium, as distinguished from a spherical coccus or rod-shaped bacillus.