Cryptic crossword clue
Fabricate without force unusual micro-organisms

The most common and most likely answer to this crossword clue is the 8 letter word BACTERIA

I've seen this crossword clue in The Guardian
B
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Buddy explains!

The straight part
We know that "micro-organisms" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case micro-organisms = bacteria.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does BACTERIA mean?

BACTERIA noun
  1. A type, species, or strain of bacterium.
  2. A derisive term for a lowlife or a slob (could be treated as plural or singular).
BACTERIA noun
  1. A single celled organism with cell walls but no nucleus or organelles.
BACTERIA noun
  1. An oval bacterium, as distinguished from a spherical coccus or rod-shaped bacillus.

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