The most common and most likely answer to this crossword clue is the 6 letter word IGNORE
I've seen this crossword clue in The Times
I
G
N
O
R
E
More clues leading to the result IGNORE
- Pay no attention to region on travels
- Disregard sign with no start, or end of message
- Take no notice of Italian gentleman losing head
- Discount from trader on gifts raised
- Fail to appreciate development of region
- Disregard Italian gentleman losing head
- Pass by one rig at sea
- Shun Italian man denied introduction
- Spurn developing region
- Region redeveloped to create bypass
Buddy explains!
The straight part
We know that "Fail to appreciate" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case fail to appreciate = ignore.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does IGNORE mean?
IGNORE verb- To deliberately not listen or pay attention to.
- To pretend to not notice someone or something.
- Fail to notice.
- Not to know.