The most common and most likely answer to this crossword clue is the 6 letter word MISSUS
I've seen this crossword clue in The Guardian
M
I
S
S
U
S
More clues leading to the result MISSUS
- National beauty title for wife?
- Wish we were here for wife
- Dutch American expats may
- Wife, loveliest woman in the States?
- Winner of American beauty pageant getting partner
- Her indoors, a beauty from the States?
- Fail to catch American wife
- American beauty queen’s wife?
- Wife, the most beautiful girl in America?
- Partner to want me?
Buddy explains!

The straight part
We know that "wife" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case wife = missus.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MISSUS mean?
MISSUS noun- Wife or girlfriend.
- Term of address for a woman.