The most common and most likely answer to this crossword clue is the 6 letter word LOSERS
I've seen this crossword clue in The Guardian
L
O
S
E
R
S
More clues leading to the result LOSERS
- Failures of devotees accepting second in place of victory
- Some mountaineers resolve to climb? They’re not successful
- Less resolution after setback? They’ll show that in part
- People who fail in ambitious resolutions turning up
- No-hopers played lacrosse losing match regularly
- Don't start relief pitchers. They don't win
Buddy explains!

The straight part
We know that "Failures" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case failures = losers.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does LOSERS mean?
LOSERS noun- A person who loses; one who fails to win or thrive.
- Something of poor quality.
- A person who is frequently unsuccessful in life.
- A contemptible or unfashionable person.
- One who or that which loses something, such as extra weight, car keys, etc.