The most common and most likely answer to this crossword clue is the 8 letter word RELAPSES
I've seen this crossword clue in The Guardian
R
E
L
A
P
S
E
S
More clues leading to the result RELAPSES
Buddy explains!

The straight part
We know that "gets worse again" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case gets worse again = relapses.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does RELAPSES mean?
RELAPSES verb- To fall back again; to slide or turn back into a former state or practice.
- (of a disease) To recur; to worsen, be aggravated (after a period of improvement).
- To slip or slide back physically; to turn back.