The most common and most likely answer to this crossword clue is the 10 letter word NOTABILITY
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More clues leading to the result NOTABILITY
Buddy explains!

The straight part
We know that "Fame" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case fame = notability.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
Crossword Answer definitions
NOTABILITY noun- The quality or state of being notable or eminent.
- A notable or eminent person or thing.
- Locally eminent people; the bourgeoisie or upper middle class