Cryptic crossword clue
Familiar poem – the first of Donne 6

The most common and most likely answer to this crossword clue is the 6 letter word VERSED

V
E
R
S
E
D


Buddy explains!

The straight part
We know that "Familiar" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case familiar = versed.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does VERSED mean?

VERSED verb
  1. To compose verses.
  2. To tell in verse, or poetry.
  3. To educate about, to teach about.
VERSED verb
  1. To oppose, to compete against, especially in a video game.
VERSED adjective
  1. Knowledgeable or skilled, either through study or experience; familiar; practiced

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