The most common and most likely answer to this crossword clue is the 5 plus 3 plus 5 letter word FLESH AND BLOOD
F
L
E
S
H
A
N
D
B
L
O
O
D
Buddy explains!
The straight part
We know that "Family" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case family = flesh and blood.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.