Cryptic crossword clue
Family disheartened after eastern places going up cause astonishment 7

The most common and most likely answer to this crossword clue is the 7 letter word STUPEFY

I've seen this crossword clue in The Daily Telegraph
S
T
U
P
E
F
Y

Buddy explains!

The straight part
We know that "cause astonishment" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case cause astonishment = stupefy.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does STUPEFY mean?

STUPEFY verb
  1. To dull the senses or capacity to think thereby reducing responsiveness; to dazzle or stun.

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