The most common and most likely answer to this crossword clue is the 12 letter word OBLITERATION
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More clues leading to the result OBLITERATION
Buddy explains!
The straight part
We know that "loss" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case loss = obliteration.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does OBLITERATION mean?
OBLITERATION noun- The total destruction of something.
- The cancellation, erasure or deletion of something.
- The cancellation of the function, structure, or both of a vessel or organ; for example, the occlusion of the lumen of a duct, blood vessel, or lymphatic vessel, be it solely functional (as when squeezed by nearby mass effect or inflammation) or both structural and functional (as when clogged with thrombus, embolus, or fibrosis).