The most common and most likely answer to this crossword clue is the 2 plus 1 plus 5 plus 2 plus 4 letter word IN A STATE OF FLUX
I've seen this crossword clue in The Daily Telegraph
I
N
A
S
T
A
T
E
O
F
F
L
U
X
Buddy explains!
The straight part
We know that "uncertain as to what should be done" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case uncertain as to what should be done = in a state of flux.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.