The most common and most likely answer to this crossword clue is the 5 letter word LIPID
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More clues leading to the result LIPID
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The cryptic/wordplay part
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What does LIPID mean?
LIPID noun- Any of a group of organic compounds including the fats, oils, waxes, sterols, and triglycerides. Lipids are characterized by being insoluble in water, and account for most of the fat present in the human body.