Cryptic crossword clue
Father initially neglected grave ache 4

The most common and most likely answer to this crossword clue is the 4 letter word PANG

P
A
N
G

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The straight part
We know that "ache" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case ache = pang.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PANG mean?

PANG noun
  1. (often in the plural) A paroxysm of extreme physical pain or anguish; a feeling of sudden and transitory agony; a throe.
  2. (often in the plural) A sudden sharp feeling of an emotional or mental nature, as of joy or sorrow.
PANG verb
  1. To cause to have great pain or suffering; to torment, to torture.

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