Cryptic crossword clue
Father Mark’s unfortunate – Casualty is anodyne 10

The most common and most likely answer to this crossword clue is the 10 letter word PAINKILLER

I've seen this crossword clue in Independent
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PAINKILLER mean?

PAINKILLER noun
  1. A drug that numbs the pain in the body.

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