Cryptic crossword clue
Father takes three directions to reach where uncle does business 8

The most common and most likely answer to this crossword clue is the 8 letter word PAWNSHOP

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Buddy explains!

The straight part
We know that "where uncle does business" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case where uncle does business = pawnshop.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PAWNSHOP mean?

PAWNSHOP noun
  1. The business premises of a pawnbroker; where loans are made, with personal property as security

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