Cryptic crossword clue
Fatuous fellow from Ohio in Republican party 4

The most common and most likely answer to this crossword clue is the 4 letter word GOOP

G
O
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Buddy explains!

The straight part
We know that "Fatuous fellow" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case fatuous fellow = goop.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GOOP mean?

GOOP noun
  1. (usually uncountable) A thick, slimy substance; goo.
  2. A silly, stupid, or boorish person.

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