Cryptic crossword clue
Favoured still a US college from the south occupied by lecturer in a familiar way 10

The most common and most likely answer to this crossword clue is the 10 letter word INTIMATELY

I've seen this crossword clue in Independent
I
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Buddy explains!

The straight part
We know that "in a familiar way" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case in a familiar way = intimately.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INTIMATELY mean?

INTIMATELY adverb
  1. In an intimate manner.

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