Cryptic crossword clue
Fed up in the morning, Anto is upset about one slur 10

The most common and most likely answer to this crossword clue is the 10 letter word DEFAMATION

I've seen this crossword clue in The Guardian
D
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Buddy explains!

The straight part
We know that "slur" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case slur = defamation.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DEFAMATION mean?

DEFAMATION noun
  1. The act of injuring another person's reputation by any slanderous communication, written or oral; the wrong of maliciously injuring the good name of another.

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