Cryptic crossword clue
Feel unwell on Friday, with extremes of torpidity and weakness 7

The most common and most likely answer to this crossword clue is the 7 letter word FRAILTY

I've seen this crossword clue in Financial Times
F
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A
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Buddy explains!

The straight part
We know that "weakness" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case weakness = frailty.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does FRAILTY mean?

FRAILTY noun
  1. The condition quality of being frail, physically, mentally, or morally; weakness of resolution; liability to be deceived or seduced.
  2. A fault proceeding from weakness; foible; sin of infirmity.

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