Cryptic crossword clue
Female noble gripped by message defying explanation 13

The most common and most likely answer to this crossword clue is the 13 letter word UNACCOUNTABLE

I've seen this crossword clue in The Times
U
N
A
C
C
O
U
N
T
A
B
L
E

Buddy explains!

The straight part
We know that "defying explanation" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case defying explanation = unaccountable.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does UNACCOUNTABLE mean?

UNACCOUNTABLE adjective
  1. Inexplicable; unable to account for, or explain.
  2. Not responsible; free from accountability or control.

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