The most common and most likely answer to this crossword clue is the 3 letter word GAL
I've seen this crossword clue in The Times
G
A
L
Buddy explains!

The straight part
We know that "Female" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case female = gal.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does GAL mean?
GAL noun- A unit of volume, equivalent to eight pints
- Exactly 4.54609 liters; an imperial gallon
- 231 cubic inches or approximately 3.785 liters for liquids (a "U.S. liquid gallon")
- One-eighth of a U.S. bushel or approximately 4.405 liters for dry goods (a "U.S. dry gallon").
- (in the plural) A large quantity (of any liquid).
- A young woman.
- A galileo (a unit of acceleration).