Cryptic crossword clue
Fiendish nurse in wacky finale 8

The most common and most likely answer to this crossword clue is the 8 letter word INFERNAL

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Buddy explains!

The straight part
We know that "Fiendish" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case fiendish = infernal.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INFERNAL mean?

INFERNAL noun
  1. An inhabitant of the infernal regions.
INFERNAL adjective
  1. Of or relating to hell, or the world of the dead; hellish.
  2. (by extension) Of or relating to a fire or inferno.
  3. Stygian, gloomy.
  4. Diabolical or fiendish.
  5. (as an expletive, not vulgar) Very annoying; damned.

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