Cryptic crossword clue
Fine organic compound's gradually become bitter 6

The most common and most likely answer to this crossword clue is the 6 letter word FESTER

I've seen this crossword clue in The Times
F
E
S
T
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Buddy explains!

The straight part
We know that "gradually become bitter" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case gradually become bitter = fester.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does FESTER mean?

FESTER noun
  1. A fistula.
  2. A sore or an ulcer of the skin.
  3. The condition of something that festers; a festering; a festerment.
FESTER verb
  1. To become septic; to become rotten.
  2. To worsen, especially due to lack of attention.
  3. To cause to fester or rankle.

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