Cryptic crossword clue
Fine pals excited in every minute of existence

The most common and most likely answer to this crossword clue is the 8 letter word LIFESPAN

I've seen this crossword clue in The Guardian
L
I
F
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P
A
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Buddy explains!

The straight part
We know that "every minute of existence" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case every minute of existence = lifespan.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does LIFESPAN mean?

LIFESPAN noun
  1. The length of time for which an organism lives.
  2. (by extension) The length of time for which something exists or is current or valid.

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